SALIVA AND SERUM MALONDIALDEHYDE LEVELS IN APPARENTLY HEALTHY INDIVIDUALS IN KURDISTAN REGION / IRAQ

NAZDAR M. OMER; QASIM H. ABDULLAH; HAZHMAT A. ALI

NAZDAR M. OMER Department of Medical Physiology and Pharmacology, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
QASIM H. ABDULLAH Department of Medical Physiology and Pharmacology, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
HAZHMAT A. ALI Department of Medical Physiology and Pharmacology, College of Medicine, University of Duhok, Kurdistan Region, Iraq

Keywords: Malondialdehyde, , Periodontal disease

Abstract

https://doi.org/10.31386/dmj.2017.11.2.2

Background: Saliva is a fluid secreted by the salivary glands and it is divided in to serous and mucus components. Despite its physiological roles in lubricating the oral cavity and digestion, it also acts as a simple diagnostic tool reflecting body's systemic diseases. The aim of the present study is to determine malondialdehyde (MDA) levels in saliva and serum of apparently healthy individuals and to find if there is an association between dental caries, periodontal disease and salivary MDA.

Subject and Methods: This cross sectional study involved sixty fourparticipants who were medical students attending Duhok College of Medicine. Clinical information and all relevant data were obtained according to a questionnaire. Both salivary and serum MDA levels were measured manually in unstimulated saliva and sera of participants using Thiobarbuturic acid method.

Results: Malondialdehyde is measurable in saliva of apparently healthy individuals and was significantly lower than serum MDA level (p<0.001). There was a statistically highly significant positive correlation between both salivary and serum MDA levels (p=0.0007). Moreover, both Salivary and serum MDA levels were significantly positively correlated with weight and BMI (p=0.03, p=0.03 and p= 0.04 and 0.05) respectively. There were no significant correlations between salivary MDA with dental caries index (dmft score) and periodontal disease index.

Conclusions: Based on the current results, salivary MDA is significantly positively correlated with serum MDA, weight and BMI. No significant association of salivary MDA with dental caries and periodontal disease were observed.

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