UTERINE MESENCHYMAL TUMORS IN DUHOK-IRAQ. A PRACTICAL PATHOLOGICAL STUDY

INTISAR SALIM PITY; SUAD TAHER YASEN; BANAV NAJEEB MUHAMMED; OMAR SALIM MUHI; AZAD MUSTAFA AHMAD; FADI BADAL HAYDER

INTISAR SALIM PITY Prof, Pathology Dep., College of Medicine, University of Duhok, Duhok, Kurdistan Region of Iraq.
SUAD TAHER YASEN Lecturer, Obstetrics & Gynecology Dep., College of Medicine, University of Duhok, Kurdistan Region of Iraq.
BANAV NAJEEB MUHAMMED Lecturer, Obstetrics & Gynecology Dep., College of Medicine, University of Duhok, Kurdistan Region of Iraq.
OMAR SALIM MUHI Director of Health Duhok, Duhok, Kurdistan region of Iraq.
AZAD MUSTAFA AHMAD Lecturer, Basic Sciences Dep, College of Dentistry, University of Duhok, Duhok, Kurdistan Region of Ira
FADI BADAL HAYDER Director of Health Duhok, Duhok, Kurdistan region of Iraq.

Keywords: Diagnosis, Immunohistochemistry, Mesenchymal tumors, Uterus

Abstract

https://doi.org/10.31386/dmj.2023.17.2.8

Background: Although malignant uterine mesenchymal tumors are relatively uncommon, their definite diagnosis is crucial for therapeutic as well as prognostic purposes.

Objectives: To study the frequency of uterine mesenchymal tumors in Duhok-Iraq and to highlight the impact of immunohistochemically on warning cases.

Materials and Methods: In this cross-sectional study, 3931 uterine mesenchymal tumors were received in the Departments of Histopathology in Vin Private Laboratories and Central General Laboratories in Duhok-Iraq, over a consecutive period of 13 years (January 2009 to December 2021). Cases were examined morphologically. Equivocal cases were subjected to immunohistochemical workup via UltraVision LP Large Volume Detection System & HRP Polymer (Ready-To-Use) from Thermo Fisher Scientific and using the automated immunostaining technique.

Results: Benign tumors (97.4%) overwhelmed the malignant cases (1%). The remaining 1.6% comprised the smooth muscle tumors of undetermined malignant potential (SUMPT).

Conclusions: Diagnosis and categorization of most benign and malignant uterine mesenchymal tumors is an acumen nuclear histology. However, in unequivocal cases, high-grade cancers and mixed neoplasms, immunohistochemistry is needful and applicable due to its easy methodology. Yet some cases remain doubtful and require advanced techniques for definite diagnosis.

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