OXIDANT-ANTIOXIDANT STATUS IN POSTMENOPAUSAL OSTEOPOROTIC WOMEN IN DUHOK CITY
Background and Objectives: Osteoporosis (OP) is a condition of increasing bone loss which leads to increase bone fragility and fractures. Current studies proved that oxidative stress (OS) has involved in bone resorption. Thus, this study aimed to compare the serum levels of oxidative stress parameters between postmenopausal women with osteoporosis and without osteoporosis to show whether there is a relationship between oxidative stress parameters and bone mineral density (BMD) or not.
Subject and Method: In this cross-sectional study, a total of 150 postmenopausal women who visited Duhok Rheumatoid Center and performed bone densitometry were enrolled. A study questionnaire was used to collect the required information from participants. Serum malondialdehyde (MDA), ceruloplasmin (CP), peroxynitrite (PN), total bilirubin (TBIL), calcium and vitamin D (VD) were studied.
Results According to world health organization (WHO) criteria, normal BMD was determined in 12% of the study population, women with osteopenia represented 52% and 36% of women were identified as having OP. Women with OP had significantly higher mean values of MAD, PN and CP as compared to controls. Mean values of TBIL and calcium remained unchanged. Similarly, VD showed no significant differences between groups with high prevalence of VD deficiency among the study population. This study showed a negative significant correlation between total BMD, lumbar spine (L-spine) BMD and MDA in women with OP.
Conclusions: The present study suggests that oxidative stress parameters may be valuable in diagnosis of low bone mass in postmenopausal women. However, more studies assessing the role of oxidative stress in bone metabolism are needed.
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