• LUMA HAMEED AHMED Directorate of duhok health, Department of Dermatology, Duhok, Kurdistan Region, Iraq
  • DHIA J AL-TIMIMI Professor in clinical biochemistry, College of Medicine, University of Duhok, Kurdistan Region of Iraq
  • BARZAN KHALID SHARAF Directorate of duhok health, Department of Dermatology, Duhok, Kurdistan Region, Iraq
Keywords: Acne vulgaris, Serum zinc status


 Background: There is increasing evidence on the association between low serum zinc levels and acne vulgaris; there are some reports on Zinc level and severity of acne vulgaris. The aim of the study was to measure the level of serum zinc in patients with acne vulgaris and to ascertain the impact of zinc on its severity.

Materials and Methods: This study was conducted at Azadi Teaching Hospital, Duhok city, Kurdistan Region - Iraq, throughout the period from the 1st of January to the 30th of April 2019. It was a case-control study Design, in which 100 patients with acne vulgaris and 100 apparently healthy controls without acne vulgaris were enrolled. The two groups were matched for age, sex and body mass index.

Levels of serum zinc, triglycerides and albumin were measured. The classification of acne severity was done according to the American Academy of Dermatology Acne Consensus Conference.

Results: Significantly, higher prevalence of hypozincemia (p=0.017) were found in acne vulgaris patients than in apparently healthy controls without acne vulgaris. Significant lower zinc/Triglycerides ratio and zinc /albumin ratio was observed in the patients’ group compared to apparently healthy controls without acne vulgaris. In patients with acne vulgaris, serum zinc correlated positively with zinc/ Triglycerides and zinc/albumin ratio (p =0.001 and <0.001 respectively). Statistically, there were no significant differences (p>0.05) between patients with different forms of acne regarding the zinc level and other parameters.

Conclusions: Low level of serum zinc has been found in patient with acne vulgaris especially those with severe form of the disease, but there is no relation between low serum zinc levels and the severity of the acne vulgaris.


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