THE ROLE OF INTERLEUKIN - 1 IN POSTPRANDIAL SOMNOLENCE IN  DUHOK CITY, KURDISTAN REGION OF IRAQ

Farsat Saeed Saadi; Bland Bayar Khaleel

Farsat Saeed Saadi Ministry of Health - Kurdistan Region of Iraq
Bland Bayar Khaleel Diabetologist, Azadi Teaching Hospital, Duhok Governorate.

Keywords: Interleukin-1, Postprandial Somnolence, Inflammation, Stanford Sleepiness Scale

Abstract

https://doi.org/10.31386/dmj.2025.19.1.3

Background: Many research studies have been conducted to understand the role of different interleukins in pathogenesis and/or treatment of diseases, majority of results are promising. Interleukin 1 plays a master role in inflammatory processes and innate immune mechanisms. Feeling drowsy or somnolence has been linked to IL-1. The current study aimed to examine the role of IL-1 in postprandial somnolence in both lean and obese individuals.

Methods: This is a cross-sectional study investigating the role of IL-1 level on postprandial somnolence. A sample of 88 healthy male and female participants recruited in the study, age between 18 and 65 years old and usually had breakfast at least three hours before being tested. The Stanford Sleepiness Scale (SSS) used as a validated method to measure subjective sleepiness.

Results: The result showed statistically significant correlation between IL-1 level and postprandial somnolence. Around 72% had postprandial somnolence (rated 4 and above in SSS),16% had dozing (rated 3 in SSS) and only 12% were normal (rated 1 and 2 in SSS). Subjects with postprandial somnolence and dozing (78 out of 88 subjects) counted as 88% of the sample, 67% had high level of IL-1 and 67% were obese and 33% were lean.

Conclusions: It was found that IL-1 is correlated with postprandial somnolence and dozing, further in-depth research studies to understand the role of interleukins especially IL-1 are necessary.

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