DNA damage and Lipid parameters among healthy smokers and non-smokers in Duhok, Kurdistan region of Iraq.

hivi mohammed mahmoud

hivi mohammed mahmoud College of Medicine-University of Duhok, Kurdistan Region of Iraq

Keywords: DNA damage, smoking habit, lipid profile, healthy men

Abstract

https://doi.org/10.31386/dmj.2025.19.1.8

Objective: Oxidative DNA damage has been linked to smoking habit in several populations. This study investigated the level of oxidative DNA damage among healthy smokers and non-smokers.

Methods: The present study investigated 8-hydroxy-2-deoxiguanosine (8-OHdG), malondialdehyde (MDA), and lipid profile in a sample of Kurdish individuals attended out -Patient Department (OPD) of Medicine at Azadi Teaching Hospital in Duhok city, Kurdistan Region, Iraq, as attendant of patients. The study included a total of 410 volunteers, of which 170 were smokers and 240 were non-smokers.

Results: In those with smoking habit, significantly higher 8-OHdG and MDA levels was found compared to the non-smokers. A similar pattern was observed when comparing total cholesterol (TC) and Low density lipoprotein-cholesterol (LDL-C). In the smoker group, a positive correlation was observed between 8-OHdG with TC and a negative correlation with high density lipoprotein-cholesterol (HDL-C), with both patterns being statistically significant.

Conclusion: The results of this study showed elevated levels of 8-OHdG and MDA in conjunction with abnormal lipid profile in those with smoking habit which may be a strong indicator of oxidative DNA damage in the Kurdish population.

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