PAPILLARY THYROID CARCINOMA WITH COEXISTENCE OF HASHIMOTO AND TUMOR-ASSOCIATED LYMPHOCYTES
Abstract
https://doi.org/10.31386/dmj.2025.19.2.4
Background and objectives: Papillary thyroid carcinoma represents the most common thyroid cancer. The co-existence of Hashimoto thyroiditis and papillary thyroid carcinoma has long been described in clinical research; however, the relationship is still debatable. Recent data depicted that the pre-existing thyroiditis positively impacts the development and progression of papillary thyroid carcinoma. This study aimed to investigate the co-existence of Hashimoto thyroiditis and papillary thyroid carcinoma and their correlation with immunological markers expression, including CD19 and IgG4, and with the clinicopathological factors.
Methods: The research conducted a retrospective investigation evaluating thyroid tissue obtained from papillary thyroid carcinoma patients with Hashimoto thyroiditis or non-specific thyroiditis coexistence. The examination determined B-cell and plasma cell infiltration using CD19 and IgG4 markers analysis to correlate them statistically with demographic and clinicopathological factors.
Results: Showed coexistence of Hashimoto thyroiditis and non-specific thyroiditis with papillary thyroid carcinoma in 74%, with a significant association between IgG4-related disease with age and the histological subtypes. The IgG-related disease manifests primarily in patients below 45 years, particularly among those with Hashimoto thyroiditis. In contrast, other clinicopathological findings showed no correlation to inflammation and immunological markers.
Conclusions: For patients aged under 45 years, IgG4-related disease was predominant, especially those with Hashimoto thyroiditis. The percentage of female patients was higher in the Hashimoto thyroiditis group with CD19-positivity than in non-specific thyroiditis patients, without a correlation between CD19 expression and age. Papillary thyroid carcinoma presenting with Hashimoto thyroiditis and IgG4 expression, particularly for CD19 expression, defines different immunological markers that require further evaluation regarding the potential prognostic relevance.
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College of Medicine, University of Duhok
Duhok, Iraq
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