EFFICACY OF HYALURONIC ACID GEL WITH CORONALLY ADVANCED FLAP IN THE TREATMENT OF GINGIVAL RECESSION: A RANDOMIZED CLINICAL TRIAL
Abstract
https://doi.org/10.31386/dmj.2025.19.2.9
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Abstract
Background: Gingival recession (GR) impairs aesthetics and causes root sensitivity, requiring predictable root coverage. The coronally advanced flap (CAF) is the gold standard for Miller Class I defects; however, it yields variable outcomes. This study aimed to evaluate adjunctive 0.8% or 0.2% hyaluronic acid (HA) gel for enhancing CAF efficacy in GR treatment.
Materials and methods: This double-blind, three-arm, randomized controlled clinical trial was conducted on 30 patients with localized Miller Class I gingival recession (≥ 2 mm) who were randomized into three groups: Group A (n = 10, CAF + 0.8% HA). Group B (n = 10, CAF + 0.2% HA). Group C (n = 10, CAF alone). All clinical parameters, including recession depth (RD), width of keratinized gingiva (WKG), probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), gingival index (GI) and root coverage percentage (RC%), were measured at baseline and one-month and three-month follow-up.
Results: After 3 months, the three groups demonstrated statistically significant improvement from baseline (p < 0.05). Group A showed the greatest reduction in RD (from 3mm to 1mm) and the highest RC (66.7%) followed by group B with RD reduction (3mm to 1.75mm) and RC (50%), and group C with RD reduction (3.5mm to 2.75 mm) and RC (15.5%). CAL gain and PPD reduction were also significantly greater in group A than the other groups. No statistically significant intergroup differences were observed in WKG, PI, or GI.
Conclusion: In the treatment of Miller Class I gingival recessions, the adjunctive use of 0.8% HA with CAF significantly improves root coverage, RD reduction, and CAL gain over both 0.2% HA and CAF alone.
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