OXIDANT-ANTIOXIDANT STATUS IN POSTMENOPAUSAL OSTEOPOROTIC WOMEN IN DUHOK CITY
Keywords:
Osteoporosis, postmenopause, oxidative stress, malondialdehyde, peroxynitrite, ceruloplasmin
Abstract
https://doi.org/10.31386/dmj.uod.18.12.2.6
Background and Objectives: Osteoporosis (OP) is a condition of increasing bone loss which leads to increase bone fragility and fractures. Current studies proved that oxidative stress (OS) has involved in bone resorption. Thus, this study aimed to compare the serum levels of oxidative stress parameters between postmenopausal women with osteoporosis and without osteoporosis to show whether there is a relationship between oxidative stress parameters and bone mineral density (BMD) or not.
Subject and Method: In this cross-sectional study, a total of 150 postmenopausal women who visited Duhok Rheumatoid Center and performed bone densitometry were enrolled. A study questionnaire was used to collect the required information from participants. Serum malondialdehyde (MDA), ceruloplasmin (CP), peroxynitrite (PN), total bilirubin (TBIL), calcium and vitamin D (VD) were studied.
Results According to world health organization (WHO) criteria, normal BMD was determined in 12% of the study population, women with osteopenia represented 52% and 36% of women were identified as having OP. Women with OP had significantly higher mean values of MAD, PN and CP as compared to controls. Mean values of TBIL and calcium remained unchanged. Similarly, VD showed no significant differences between groups with high prevalence of VD deficiency among the study population. This study showed a negative significant correlation between total BMD, lumbar spine (L-spine) BMD and MDA in women with OP.
Conclusions: The present study suggests that oxidative stress parameters may be valuable in diagnosis of low bone mass in postmenopausal women. However, more studies assessing the role of oxidative stress in bone metabolism are needed.
Downloads
Download data is not yet available.
References
1-Aggarwal N, Raveendran A, Khandelwal N, Sen R K, Thakur J S, Dhaliwal L K, et al. Prevalence and related risk factors of osteoporosis in pre- and postmenopausal Indian women. J of Mid-life Health. 2011; 2 (2): 81-5.
2-Bartl RB and Frisch B. Osteoporosis: Diagnosis, prevention, therapy. 2nd ed. USA: Springer – Verlag; 2009. P. 2-39.
3-Ferdous HS, Afsana F, Qureshi NK and Rouf RS.Osteoporosis: A review. Birdem Med J. 2015; 5 (1): 30-36.
4-Deveci HA, Nur G, Cicek H and Karapehlivan M. Evaluation of oxidative stress factors in patients with osteoporosis. Med Sci. 2017; 6 (3):479-82.
5-Prentice A. Diet, nutrition and the prevention of osteoporosis. Puplic Health Nutr. 2004; 7(1A): 227–43.
6-Lee YJ, Hong JY, Kim SC, Joo JK, Na Yand Lee KS. The association between oxidative stress and bone mineral density according to menopausal status of Korean women. Obstet Gynecol Sci. 2015; 58 (1):46-52.
7-Altindag O, Erel O, Soran N, Celik H and Selek S. Total oxidative/anti-oxidative status and relation to bone mineral density in osteoporosis. Rheumatol Int. 2008; 28:317-21.
8-Jannata B, Oveisib M, Sadeghib N, Hajimahmoodib M, Jamshidic A, Dolaghb GI, et al. The erythrocyte catalase enzyme activity in Iranian osteoporotic women. IJPS Winter. 2010; 6(1): 19-24.
9-Nortin T, Husameetin E and Ilhim S. Measurement of total Malondialdehyde in plasma and tissues by high performance liquid chromatography and thiobarbituric acid assay. Firat Tip Dergisi. 2006; 11:88-92.
10-VanUffelen BE, Zee V D J, Ben M D E K, vanSteveninck J andElferink J G R. Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration. Biochem J. 1998; 722 (330):719–22.
11-Menden E, Boiano JM Lalitha M and Petering HG. Modification of a p-phenylenediamine oxidase method to permit non-automated ceruloplasmin determinations in batches of rat serum or plasma microsamples. Analytical Letters. 1977; 10(3):197–204.
12-Chavan SN, More U, Mulgund S, Saxena V and Sontakke AN. Effect of supplementation of vitamin C and E on oxidative stress in osteoporosis. Ind J of Clin Bioch. 2007; 22 (2): 101-5.
13-Sontakke AN, Tare RS. A duality in the roles of reactive oxygen species with respect to bone metabolism. Clin Chim Acta. 2002; 318:145–8.
14-Maggio D, Barabani M, Pierandrei M, Polidori C, Catani M, Mecocci P, et al. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab. 2003; 88:1523–27.
15-Yilmaz A, Sari RA, Gundogdu M, Kose N and Dag E. Trace elements and some extracellular antioxidant proteins levels in serum of patients with systemic lupus erythematosus. Clin Rheumatol. 2005; 24: 331–5.
16-Engström G, Segelstorm N, Ekberg-Aronsson M, Nilsson PM and Lindgarde F, Lofdahl C. Plasma markers of inflammation and incidence of hospitalizations for COPD: results from a population-based cohort study. Thorax. 2009; 64: 211–215.
17-Goldring SR and Gravallese EM. Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications. Arthritis Res. 2000; 2(1):33–37.
18-Karakas EY, Yetisgin A, Cadirci D, Sezen H, Altunbas R, Kas F, et al. Usefulness of ceruloplasmin testing as a screening methodology for geriatric patients with osteoporosis. J Phys Ther Sci. 2016; 28: 235-239.
19-Cervellati C, Bonaccorsi G, Cremonini F, Romani A, Fila E, Castaldini MC, et al. Oxidative stress and bone resorption interplay as a possible trigger for postmenopausal osteoporosis. Bio Med Research International. 2014. DOI: org/10.1155/2014/569563.
20-Hikiji H, Shin WS, Koizumi T, Takato T, Susami T, Koizumi Y, et al. Peroxynitrite production by TNF-α and IL-1β: implication for suppression of osteoblastic differentiation. Amer J Physiol Endocrinol Metab. 2000; 278: 1031–1037.
21-Ljubuncic P, Gochma E and Reznick AZ. Nitrosative stress in aging –its importance and biological implications in NF-ҡB signaling. In: Bondy S and Maiese K, editors, Aging and age-related disorders. Human Press Inc; 2010; P. 25-56.
22-Rocha FA and Brum-Fernandes AJ. Evidence that peroxynitrite affects human osteoblast proliferation and differentiation. J of Bone and Mineral Research. 2002; 17(3): 434- 442.
23-Ruiz-Gaspa S, Martinez-Ferrer A, Guanabens N, Dubreuil M, Peris P, Enjuanes A, et al. Effects of bilirubin and sera from jaundiced patients on osteoblasts: contribution to the development of osteoporosis in liver diseases. Hepatology. 2011; 54:2104–2113.
24-Cho JH, Kim MT, Lee HK, Hong IS and Jang HC. Factor analysis of biochemical markers associated with bone mineral density in adults. J Phys Ther Sci. 2014; 26: 1225-1229.
25-Kim BJ, Koh JM, Ahn SH, Lee SH, Kim EH, Bae SJ, et al. High serum total bilirubin as a protective factor against hip bone loss in healthy middle-aged men. Calcif Tissue Int. 2013; 92: 501-518.
26-Yan P, Zhang Z, Feng J, Li H, Gao C, Yang J, et al. Association between serum total bilirubin levels, bone mineral density, and prevalence of osteoporosis in Chinese patients with type 2 diabetes. Int J Clin Exp Pathol. 2017; 10 (5):5784-5798.
27-Ali NK. Estimation of some mineral (calcium, phosphorous, vitamin 25 (OH) D and alkaline phosphatase) in osteoporosis patients in Kirkuk city. J Osteopor Phys Act. 2018; 6 (2).
28-Alkhenizan A, Mahmoud A, Hussain A, Gaber A, Alsoghayer S and Eldali A. The relationship between 25(OH) D levels and bone mineral density in a Saudi population in a community based setting. PLoS One. 2017; 12 (1). DOI:10.1371/journal. pone.0169122.
29-Huong NT. Osteoporosis: A major health problem in Vietnam, lifestyle factors and determinants of bone mass. 2012. Ph.D. Thesis. Karolinska Institutet, Sweden.
30-Stevenson JC and Marsh MS. An atlas of osteoporosis.3rd ed. UK: Informa UK Ltd; 2008. P. 21-29.
31-Tsai M. The relationship between osteoporosis knowledge, beliefs and dietary calcium intake among south Asian women in Auckland. 2008; M. Sc. Thesis, Massey University, New Zealand.
32-Hyassat D, Alyan T, Jaddou H and Ajlouni KM. Prevalence and risk factors of osteoporosis among Jordanian postmenopausal women attending the National Center for diabetes, endocrinology and genetics in Jordan. Bio Research Open Access. 2017; 6 (1).85-93.
33-Sahmani M, Omidian S, Javadi A, Sabet MS and Abbasi M. Association between the serum levels of zinc, copper and lipid profile with osteoporosis in Iranian postmenopausal women. Biotech Health Sci. 2014; 1(1). DOI: 10.17795/bhs-19190.
34-Gaugris S, Heaney R, Boonen S, Kurth H, Bentkover JD and Sen SS. Vitamin D inadequacy among postmenopausal women: a systematic review. QJM. 2005; 98: 667-676.
2-Bartl RB and Frisch B. Osteoporosis: Diagnosis, prevention, therapy. 2nd ed. USA: Springer – Verlag; 2009. P. 2-39.
3-Ferdous HS, Afsana F, Qureshi NK and Rouf RS.Osteoporosis: A review. Birdem Med J. 2015; 5 (1): 30-36.
4-Deveci HA, Nur G, Cicek H and Karapehlivan M. Evaluation of oxidative stress factors in patients with osteoporosis. Med Sci. 2017; 6 (3):479-82.
5-Prentice A. Diet, nutrition and the prevention of osteoporosis. Puplic Health Nutr. 2004; 7(1A): 227–43.
6-Lee YJ, Hong JY, Kim SC, Joo JK, Na Yand Lee KS. The association between oxidative stress and bone mineral density according to menopausal status of Korean women. Obstet Gynecol Sci. 2015; 58 (1):46-52.
7-Altindag O, Erel O, Soran N, Celik H and Selek S. Total oxidative/anti-oxidative status and relation to bone mineral density in osteoporosis. Rheumatol Int. 2008; 28:317-21.
8-Jannata B, Oveisib M, Sadeghib N, Hajimahmoodib M, Jamshidic A, Dolaghb GI, et al. The erythrocyte catalase enzyme activity in Iranian osteoporotic women. IJPS Winter. 2010; 6(1): 19-24.
9-Nortin T, Husameetin E and Ilhim S. Measurement of total Malondialdehyde in plasma and tissues by high performance liquid chromatography and thiobarbituric acid assay. Firat Tip Dergisi. 2006; 11:88-92.
10-VanUffelen BE, Zee V D J, Ben M D E K, vanSteveninck J andElferink J G R. Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration. Biochem J. 1998; 722 (330):719–22.
11-Menden E, Boiano JM Lalitha M and Petering HG. Modification of a p-phenylenediamine oxidase method to permit non-automated ceruloplasmin determinations in batches of rat serum or plasma microsamples. Analytical Letters. 1977; 10(3):197–204.
12-Chavan SN, More U, Mulgund S, Saxena V and Sontakke AN. Effect of supplementation of vitamin C and E on oxidative stress in osteoporosis. Ind J of Clin Bioch. 2007; 22 (2): 101-5.
13-Sontakke AN, Tare RS. A duality in the roles of reactive oxygen species with respect to bone metabolism. Clin Chim Acta. 2002; 318:145–8.
14-Maggio D, Barabani M, Pierandrei M, Polidori C, Catani M, Mecocci P, et al. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab. 2003; 88:1523–27.
15-Yilmaz A, Sari RA, Gundogdu M, Kose N and Dag E. Trace elements and some extracellular antioxidant proteins levels in serum of patients with systemic lupus erythematosus. Clin Rheumatol. 2005; 24: 331–5.
16-Engström G, Segelstorm N, Ekberg-Aronsson M, Nilsson PM and Lindgarde F, Lofdahl C. Plasma markers of inflammation and incidence of hospitalizations for COPD: results from a population-based cohort study. Thorax. 2009; 64: 211–215.
17-Goldring SR and Gravallese EM. Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications. Arthritis Res. 2000; 2(1):33–37.
18-Karakas EY, Yetisgin A, Cadirci D, Sezen H, Altunbas R, Kas F, et al. Usefulness of ceruloplasmin testing as a screening methodology for geriatric patients with osteoporosis. J Phys Ther Sci. 2016; 28: 235-239.
19-Cervellati C, Bonaccorsi G, Cremonini F, Romani A, Fila E, Castaldini MC, et al. Oxidative stress and bone resorption interplay as a possible trigger for postmenopausal osteoporosis. Bio Med Research International. 2014. DOI: org/10.1155/2014/569563.
20-Hikiji H, Shin WS, Koizumi T, Takato T, Susami T, Koizumi Y, et al. Peroxynitrite production by TNF-α and IL-1β: implication for suppression of osteoblastic differentiation. Amer J Physiol Endocrinol Metab. 2000; 278: 1031–1037.
21-Ljubuncic P, Gochma E and Reznick AZ. Nitrosative stress in aging –its importance and biological implications in NF-ҡB signaling. In: Bondy S and Maiese K, editors, Aging and age-related disorders. Human Press Inc; 2010; P. 25-56.
22-Rocha FA and Brum-Fernandes AJ. Evidence that peroxynitrite affects human osteoblast proliferation and differentiation. J of Bone and Mineral Research. 2002; 17(3): 434- 442.
23-Ruiz-Gaspa S, Martinez-Ferrer A, Guanabens N, Dubreuil M, Peris P, Enjuanes A, et al. Effects of bilirubin and sera from jaundiced patients on osteoblasts: contribution to the development of osteoporosis in liver diseases. Hepatology. 2011; 54:2104–2113.
24-Cho JH, Kim MT, Lee HK, Hong IS and Jang HC. Factor analysis of biochemical markers associated with bone mineral density in adults. J Phys Ther Sci. 2014; 26: 1225-1229.
25-Kim BJ, Koh JM, Ahn SH, Lee SH, Kim EH, Bae SJ, et al. High serum total bilirubin as a protective factor against hip bone loss in healthy middle-aged men. Calcif Tissue Int. 2013; 92: 501-518.
26-Yan P, Zhang Z, Feng J, Li H, Gao C, Yang J, et al. Association between serum total bilirubin levels, bone mineral density, and prevalence of osteoporosis in Chinese patients with type 2 diabetes. Int J Clin Exp Pathol. 2017; 10 (5):5784-5798.
27-Ali NK. Estimation of some mineral (calcium, phosphorous, vitamin 25 (OH) D and alkaline phosphatase) in osteoporosis patients in Kirkuk city. J Osteopor Phys Act. 2018; 6 (2).
28-Alkhenizan A, Mahmoud A, Hussain A, Gaber A, Alsoghayer S and Eldali A. The relationship between 25(OH) D levels and bone mineral density in a Saudi population in a community based setting. PLoS One. 2017; 12 (1). DOI:10.1371/journal. pone.0169122.
29-Huong NT. Osteoporosis: A major health problem in Vietnam, lifestyle factors and determinants of bone mass. 2012. Ph.D. Thesis. Karolinska Institutet, Sweden.
30-Stevenson JC and Marsh MS. An atlas of osteoporosis.3rd ed. UK: Informa UK Ltd; 2008. P. 21-29.
31-Tsai M. The relationship between osteoporosis knowledge, beliefs and dietary calcium intake among south Asian women in Auckland. 2008; M. Sc. Thesis, Massey University, New Zealand.
32-Hyassat D, Alyan T, Jaddou H and Ajlouni KM. Prevalence and risk factors of osteoporosis among Jordanian postmenopausal women attending the National Center for diabetes, endocrinology and genetics in Jordan. Bio Research Open Access. 2017; 6 (1).85-93.
33-Sahmani M, Omidian S, Javadi A, Sabet MS and Abbasi M. Association between the serum levels of zinc, copper and lipid profile with osteoporosis in Iranian postmenopausal women. Biotech Health Sci. 2014; 1(1). DOI: 10.17795/bhs-19190.
34-Gaugris S, Heaney R, Boonen S, Kurth H, Bentkover JD and Sen SS. Vitamin D inadequacy among postmenopausal women: a systematic review. QJM. 2005; 98: 667-676.
Published
2018-12-31
How to Cite
KADHIM ISSA, N., & MOHAMMED AHMED, F. (2018). OXIDANT-ANTIOXIDANT STATUS IN POSTMENOPAUSAL OSTEOPOROTIC WOMEN IN DUHOK CITY. Duhok Medical Journal, 12(2), 68-80. Retrieved from https://dmj.uod.ac/index.php/dmj/article/view/57
Section
Articles
